Endocrine Abstracts

Background: Differentiated Thyroid Carcinomas (DTC) represent more than 90% of thyroid tumors with good prognosis and long survival. Currently, patients with intermediate/high risk nodule as assessed by cytological staging may undergo surgery. According to ATA 2017 guidelines, all patients presenting thyroid nodules with suspicious ultrasound features (hypoechoic pattern, irregular margins, microcalcifications, etc.) and cytopathology TIR3B, TIR4 or TIR5 according to 2014-SIAP...

Introduction: Although it has been suggested that there is a strong association between acromegaly and premalignant colonic lesions and colon cancer, it seems that in real – life practice the adherence to ACRO colonoscopy guidelines might be lower than expected (as recently shown by M.Parolin et cols).Methods: We retrospectively reviewed the case records of the 54 patients with acromegaly seen in our center since 1994.We analyzed the findings of 27 ...

IntroductionThe management of patients with adrenal incidentaloma (AI) and mild autonomous cortisol secretion (MACS) is debated. This randomized study aimed to evaluate the effects of adrenalectomy on arterial hypertension (AH), glucose and lipid metabolism.MethodsWe consecutively evaluated 626 AI patients (referred to 3 Italian Centers between 06/2016 and 02/2020). According to the inclusion criteria, we enr...

IntroductionIrisin is a molecule secreted from skeletal muscle and contributes to maintenance of metabolic homeostasis leading to increased energy expenditure and reducing the risk of obesity and diabetes. Literature data suggest that patients with Cushing disease have lower irisin values than controls and remission of hypercortisolism increases these values. Moreover, other plasma inflammation markers implicated in the pathogenesis of atherosclerosis, i...

IntroductionPrimary autoimmune hypophysitis (PAHs) is a rare inflammatory disease of the pituitary gland. Although largely investigated, the pathogenesis of PAH is not completely clarified. We aimed to investigate the immune response in PAHs.Material and methodsSerum anti-pituitary and anti-hypothalamus antibodies (respectively APAs and AHAs) were investigated though an indirect immunofluorescence on monkey h...

Background: Cell membrane fluidity of erythrocytes in patients with type 2 diabetes can be influenced by glycosylation processes, changes in lipid homeostasis and oxidative stress.Objectives: We have measured red blood cell membrane fluidity looking for differences between healthy people and diabetic subjects and also between diabetic patients affected by macroangiopathy (vascular diabetic foot) and not.Methods: We have enrolled 32...

Background: Functioning gonadotroph adenomas (GA) account for 20 to 25% of all pituitary adenomas. Clinical presentation consists in multiple ovarian follicles and cysts, higher estradiol level and endometrial hyperplasia. The treatment of choice is transphenoidal tumor resection.Case Presentation: A 40 year old woman presented with abdominal pain and menstrual cycle dysfunctions. Hormonal evaluation showed: FSH:13.8 mU/ml, estradiol:1549 pg/ml, PRL:81.7...

Background: Overt hyperthyroidism can have a negative impact on pregnancy’s outcome, if not correctly treated. Furthermore anti thyroid treatment are burned by possible side effects.Objectives: We describe the experience of our center in the management of endogenous hyperthyroidism in pregnancy. evaluating the effects of the disease and treatments on fetal and maternal health.Methods: We observed 36 pregnancies (4 twins and 1 ...

Background: Adrenocortical carcinoma (ACC) is one of the most aggressive endocrine malignancies. The Fibroblast Growth Factor/Fibroblast Growth Factor Receptor (FGF/FGFR) pathway plays a role in both embryogenesis and tumorigenesis of adrenal gland. Our group demonstrated that FGFR1-4 were upregulated in ACCs and that their high expression was significantly associated with worse prognosis, suggesting that they are potentially interesting therapeutic targets.<p class="abste...

Introduction: According to the FDA, narrow therapeutic index (NTI) medications are those in which small differences in dosage orblood concentration can lead to serious therapeutic failures and/or adverse reactions that can endanger the patient’s life or result inpersistent or significant disability or incapacity. A literature not have studies about used this medication use in endocrinology pediatric population. OBJECTIVE: Establish the prescription profil...